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doi: 10.1210/en.2008-1228
Urine pH had to be 7 before starting the infusion and maintained at this level until leucovorin rescue was completed
This is probably the reason why the persister cells were quiescent
Early events include mutation in tumor suppressive genes such as p53 (up to 64% of tumors) and p21 (up to 55% of tumors)
(August 19, 2015)
