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In addition to IGF pathways, anti-tumor effects on PI3K/AKT/mTOR and MAPK/ERK pathways with metformin exposure were observed, leading to the upregulation of markers of cell cycle arrest, apoptosis, and autophagy and downregulation of markers associated with senescence and the inhibition of cell migration (Hanna et al., 2012
Soc, 2018, 140, 1634016352
Iraqi J Pharm Sci (P-ISSN
doi: 10.1016/j.cmet.2005.06.002
