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Description
Autophagy maintains the metabolism and function of young and old stem cells

Jusko WJ, Levy G

Pyridoxal 5-phosphate (PLP) deficiency might contribute to the onset of type I diabetes

Their proposed therapeutic action is paracrine that is, they release a cocktail of bioactive molecules that: Provide neurotrophic support (BDNF, GDNF, and other factors that help surviving neurons stay alive) Reduce chronic neuroinflammation through anti-inflammatory cytokines and modulation of microglial activation Promote vascular health and support cerebral perfusion through angiogenic signals (e.g., VEGF) Provide immunomodulation that may attenuate the chronic immune dysregulation observed in PD This is a fundamentally different therapeutic concept from cell-replacement: rather than adding new dopamine producers, MSC therapy aims to slow loss of those that remain

The quality of your research depends entirely on the integrity of your components
