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J Am Med Assoc 1965;194:11719

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CYP2E1 is located predominantly in the microsomal fraction of the cytosol, but is also expressed in mitochondria [148] and a three-fold increase in this enzyme was found in hepatic mitochondria isolated from ethanol-fed rats [149]

Hormonal alterations Since stress has been described as a potential trigger for ME/CFS (422) and cause of symptom flare-ups (423, 424), it is likely that the HPA axis- the neurobiological stress system- may be implicated in ME/CFS (53, 425, 426), as well as abnormalities in growth hormone (GH) secretion and dysfunctional adrenergic metabolism (255)
