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Increased ROS levels modulate transcription factor activity, especially NF-B, activator protein-1 (AP-1) and the peroxisome proliferators-activated receptor (PPAR) family of transcriptional activators ( As a result of increasing ROS generation, one of the first events in atherogenesis, as well as in other CVDs correlated with endothelial dysfunction, is the oxidative modification of low-density lipoprotein (LDL) (Singh et al., 2002

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Thallas-Bonke V., Thorpe S.R., Coughlan M.T., Fukami K., Yap F.Y., Sourris K.C., Penfold S.A., Bach L.A., Cooper M.E., Forbes J.M