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and has received grant funding from the National Institutes of Health Research, Alzheimers Research UK, the Wellcome Trust, UK Research and Innovation, Lundbeck, and SoseiHeptares

These CD8 + T cells subsequently migrate to the tumor bed in a stem-like state, where they undergo further restimulation within the TME and develop a canonical effector program to unleash cytotoxicity upon encountering tumor cells [144]

Concurrently, dynamic monitoring by leveraging liquid biopsies, multiomic profiling, and spatial transcriptomics will track realtime tumorimmune coevolution, reveal emergent resistance mechanisms, and guide early intervention before clinical progression occurs

histolytica , indicating the potential for additional targets

doi: 10.1136/jnnp-2017-316011 257