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It is therefore assumed that each subsequent dose administered induces stronger inhibition of effector cells and increases the threshold at which clinical symptoms are induced [111]

In Studies JMEN, PARAMOUNT, and JMEI, where all patients received vitamin supplementation, incidence of Grade 3-4 neutropenia ranged from 3% to 5%, and incidence of Grade 3-4 anemia ranged from 3% to 5%

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