melanotic macule pathology outlines Lingual melanotic macule – the
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NPC1 is found bound to late endosomal membranes while NPC2 is found inside the late endosomes, early lysosomes, and in the cytosol

It is biosynthesized in vivo from lysine and methionine (Rebouche & Paulson, 1986a) in the presence of ferrous ions and the vitamins, ascorbate, niacin and pyridoxine

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