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It helps reduce swelling and inflammation in muscles, ligaments, and joints, making it effective for back pain relief

Treatment should be initiated under medical supervision to establish the underlying cause and appropriate dosing schedule

Therefore, the uncertainty resulting from some prospective studies is partially resolved, because elevated circulating homocysteine is a major independent causative risk factor for cardiovascular disease

Because safety data remains limited, patients should avoid extended cycles unless a qualified provider determines that continued use is appropriate.

In a cohort of pregnant women in Bangalore, India, with a high incidence of vitamin B-12 deficiency, we reported previously that women in the lowest tertile for plasma vitamin B-12 concentration during all 3 trimesters of pregnancy had significantly higher risk of IUGR that persisted after adjusting for maternal age, weight, education, and parity (12)