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Description
High concentrations of cytotoxic BAs (e.g., DCA) can drive microbial transcriptional reprogramming, including upregulation of efflux pumps and stress response genes, and alterations in core metabolism and BA-modifying enzyme expression (122)
In SLE mouse models, hematopoietic stem and progenitor cells (HSPCs) exhibited transcriptional reprogramming and myeloid bias
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Importantly, we compared the beneficial effects of the four peptides and did not find a statistically significant difference among their beneficial effects
