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The different hGSTP1-1 mutants show slightly altered regioselectivities in the formation of the individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations [34]

Nrf2 binds to antioxidant response elements (AREs) to enhance the expression of proteins essential for maintaining cellular redox balance [240, 241]

An increase in oxidative damage in the diabetic kidney may induce apoptosis and contribute to the development of diabetic nephropathy [312, 313, 315]

Diabetologia 38:14251433 Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R (1999) Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III study)

Egger's test did not show significant small-study bias ( p = 0.432) (Supplementary funnel diagram in Supplementary Figure 9), and sensitivity analysis confirmed the robustness of the results (Supplementary material 1)