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The significant decline in cancer mortality over the past three decades is, in part, attributable to reductions in smoking following the implementation of public health campaigns and policy initiatives

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doi: 10.1016/j.neubiorev.2025.106403

This is, therefore, a bona fide NADPH-independent disulfide reductase

Remarkably, after a 12-week resistance exercise program (leg press and extension exercises, 3 times/week), older men showed reversed age-related impairments in mitochondrial adenosine diphosphate (ADP) sensitivity, highlighting the potential of exercise to regulate the redox stress during the ageing [131]