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The disease, which was described as Shaking Palsy by its discoverer, James Parkinson in the year 1817 (Goetz, 2011), is caused primarily by death of the dopamine neurons in the Substantia nigra (SN), a region named after the high levels of melanin present in the dopamine neurons in unaffected individuals (Zecca et al., 2003)

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66 In contrast, those who were self-administering B 12 injections or who were rapidly taught to do so reported a noticeable improvement in their symptoms and quality of life, with some benefiting from increasing the frequency of injections to suit their personal need

All of the above characteristics contribute to the reduced absorption and distribution of the drug in the body [6,7]