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Helps increase calorie burning

However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]

Graefes Arch Clin Exp Ophthalmol

[DOI] [PubMed] [Google Scholar] Powers S.K., Lynch G.S., Murphy K.T., Reid M.B., Zijdewind I

Due to TMAO excretion in urine [56, 57], in chronic renal disease patients, TMAO elimination from the body fails, causing elevation of its plasma concentration [78]