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The vast majority of PI(4,5)P 2 in the cell is generated by phosphatidylinositol 4-phosphate-5 kinases (type I PIP-kinases or PIP5Ks) 3

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Structure of the PLC Catalytic Core and Its C-Terminal Extension As in most other PLC enzymes, PLC proteins share a highly conserved catalytic core composed of an N-terminal pleckstrin homology (PH) domain, four tandem EF hand repeats, a triose phosphate isomerase (TIM)like barrel domain split into X and Y halves and which houses the active site, and a C2 domain (Figs

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