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In one approach, peptides were designed to mimic HDL to bind apoE, thereby increasing apoE secretion and enhancing lipidation status to negate the impacts on A metabolism [200]

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While apoE does not cross the blood-brain barrier (BBB), it is also abundantly expressed in the central nervous system (CNS) by astrocytes, activated microglia, vascular mural cells, choroid plexus cells, and to a lesser extent in stressed neurons [3337]

Higher levels of TNF- are associated with diabetic neuropathy (Edwards 2008

Curr Alzheimer Res 8: 608614, 2011
