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It was found that ALPPS surgery caused an increase in IHH secreted by activated HSCs, and activated the HH signaling pathway in hepatocytes to promote the accumulation of GLI1 in the nucleus, thereby promoting LR (Langiewicz et al., 2017

Saccharolytic fermentation generates short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, which promote gut health and influence liver metabolism, potentially mitigating fat accumulation

557 Recent studies have found that the expression of HIF-2 may facilitate the maintenance of a pseudohypoxic state in cells, thereby promoting the onset and progression of diseases, including renal clear cell carcinoma, 558 pancreatic cancer, 559 and breast cancer

doi: 10.1200/JCO.2012.46.1574 77 Savci-HeijinkCDHalfwerkHKosterJvan de VijverMJ

( a ) Overview of barcoding experiment
