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To decipher the role of GSH in gene expressions under cold stress, transcriptome analysis of the agronomically important crop rice plants under cold stress treated with exogenous GSH was performed and resulted in upregulation of gene expression involved in transcription like DREB and ERF , hormone biosynthesis and signaling like AOS, LOX, JAZ , and SAUR in the roots (Park et al., 2021)

In HCC pathogenesis, this likely does not constitute the initial oncogenic event but may lower the genomic fidelity of hepatocytes, facilitating the accumulation of mutations and accelerating the evolution of initiated clones within the chronically injured liver

Proc Natl Acad Sci U S A (2007) 104:1228893.10.1073/pnas.0701549104 79 MandalPKSchneiderMKollePKuhlencordtPForsterHBeckHet alLoss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

Other novel treatment options In addition to the previously mentioned interventions, further analysis is warranted on studies that do not align with the previously delineated classifications