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The short answer is: likely not in the way many hope

Interestingly, these IGF1R mutants with lower negative cooperativity in IGF1 binding showed slightly weaker activation in response to IGF1 (Fig

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[DOI] [PubMed] [Google Scholar] 141.Peng H., Pan L., Ran S., Wang M., Huang S., Zhao M., Cao Z., Yao Z., Xu L., Yang Q., et al

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