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In this study, fluoride consumption reduced GSH content in testicular tissues thereby, exposed the spermatogenic cells to oxidative damage however, some bioactive component of Cyperus esculentus nut neutralizes ROS that accumulates in the testis as a result of GSH depletion by NaF, thereby complementing the endogenous antioxidants

Whether vitamin C functions as an antioxidant or pro-oxidant is determined by at least three factors: 1) the redox- potential of the cellular environment

Tumor xenograft study All mouse experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Ewha Womans University, South Korea, and conformed to ARRIVE guidelines

The hexosamine biosynthesis pathway: regulation and function

Ablation of the methylglyoxal detoxification enzyme glyoxalase I (Glo1) potentiates methylglyoxal sensitivity and reduces tumor growth in mice, arguing that targeting pathways involved in detoxification of reactive metabolites is an approach to exploit the consequences of increased glucose metabolism in cancer