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Rats received a regular diet with 49.39% of energy derived from carbohydrates, 31.67% from protein, and 18.94% from fat

This mechanism has particular relevance for athletes whose growth hormone levels fluctuate with training stress and recovery status

However, the specific antioxidative metabolites produced by metformin-treated microbiota and their anti-IIRI effects have not been fully elucidated

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A 2025 narrative review notes that standard animal safety tests have not identified a clear lethal dose at the ranges used in healing studies