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Transcriptomic analyses also indicate that elevated oxidative stress changes gene expression profiles in RPE cells, stimulating pathways that contribute to cellular senescence, angiogenesis and complement malfunction (216, 217)

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Figure 4 Figure 5 3.3 mRNA expression of genes enriched in cholesterol metabolic pathways are still significant even in the presence of inflammation In agreement with the significant differences in the transcript expression of genes involved in the GO term negative regulation of leukocyte activation ( Figure 4B ), cell assays showed that moDC stimulation with 1M Al-CPI in the presence of LPS resulted in significant decreases in the cell surface expression of CD86, HLA-DR, and PD-L1 ( Figure 5B ), although not in the levels of proinflammatory cytokines ( Supplementary Figure S2 )

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