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In addition to antibody isotype, the location and geometry of the antibody-binding epitope, stoichiometry of the antibody to antigen and affinity of the antibody for both its antigen and its cognate FcR are all crucial determinants of immune effector cell activation 21,22

Cells were grown for 5 h at 37 C in a shaking incubator at 300 rpm before seeded into a new 96-well plate with 1:20 dilution

These results are consistent with the reported role of hinge-region serine phosphorylation in the cytoplasmic retention of nuclear hormone receptors 67

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons

doi: 10.1016/j.chom.2015.10.007