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5 Clinical translational analysis Preclinical studies use rodent models, such as mice and rats, and non-human primates, including rhesus monkeys and Beagle dogs, to assess the penetration efficiency of BBB, the targeting ability of vectors, and the efficacy of these vectors (Xinyi et al., 2023)

Phase one of this four-phase trial has already concluded that TZP reduced systolic blood pressure (SBP) in 2,539 obese patients compared to placebos

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doi:10.1016/j.molmed.2017.08.001 Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ

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