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GSTs as regulators of the MAP kinase pathway The first GST described was originally identified as ligandin due to its ability to interact covalently and noncovalently with various compounds that are not substrates for enzymatic activity, including steroids, thyroid hormones, bile acid, bilirubin, and heme (Litwack et al , 1971

Nature Protocols, 1(2), 848858

Pinocytosis appears to be important for the transport of some big molecules (e.g., insulin across the blood brain barrier), but not for small molecules like most drugs

[DOI] [PubMed] [Google Scholar] 399.Yang P