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The increase in median survival of the combined cohort of C/EBP uORF mice (males & females) was 10.5% (with a significant increase in overall survival p=0.0323 log-rank test, n=100) ( figure supplement 2 and Table supplement 1 )

Impairments in fructose metabolism and elevated glucose levels, similar to our findings, have previously been reported in ruminants with reduced glucose tolerance and impairments in metabolic health [52]