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In fact, oxidative stress can lead to the decrease of DNA-binding activities of activator protein-1 and CREB (cyclic AMP-response element-binding protein) which is associated with the reduction of BDNF (brain-derived neurotrophic factor) gene expression, as well as oxidative stress, and can result in impairment of NMDA channel function that is related to the decrease in BDNF gene expression

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A patient may feel better for a few days after an intervention and then return to the same cycle of weakness, fatigue, and dependence
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Thiamine deficiency (vitamin B1 deficiency) can cause a range of symptoms, from fatigue to paralysis
