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We then evaluate in vivo and in vitro experimental models according to the disease stage and pathogenic processes they best recapitulate

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Besides mitigating alcohol-induced oxidative stress in the liver, studies have demonstrated that ALDH2 is pivotal in alcohol-induced intestinal permeability, intestinal epithelial barrier dysfunction, and gut bacterial translocation

The small molecules potentially targeting the aberrantly activated zinc transporters have been summarized in Table 1

36 Yet, these compensatory mechanisms are often inadequate during high-speed or unpredictable movements, leading to a heightened risk of instability