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[DOI] [PubMed] [Google Scholar] 34.Li YSJ, Haga JH, Chien S
It is also advised to avoid mega doses of pyridoxine in pregnant or breastfeeding patients unless necessary, since safety data for doses beyond the recommended dietary allowance are limited

Step therapy, also known as fail-first or step protocol, is another restriction in which your health insurance company may ask you to try cheaper medications (such as generics) before moving up to more expensive ones like Repatha
