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10.1002/biof.75 29 GalliF.BonominiM.BartoliniD.ZatiniL.ReboldiG.MarcantoniniG.et al (2022)

CRISPR-cas12a-assisted recombineering in bacteria

This produces mutagenic and carcinogenic byproducts, including 8-hydroxy-2-deoxyguanosine (8-OHdG), 4-hydroxy-nonenal (4HNE) modifications, and malondialdehyde (MDA), resulting in lipid peroxidation, protein modification, and DNA oxidative damage 60
To reduce the melasma, you need to break down the excess melanin that formed the patch

Cell Oncol (Dordrecht) (2015) 38(5):36575
