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Difference Between Melanotan 1 and Melanotan 2 Although often mentioned together, Melanotan 1 and Melanotan 2 are structurally and functionally distinct peptides: Melanotan 1 (Afamelanotide): Higher selectivity for MC1 receptors Primarily associated with pigmentation research Developed with a focus on skin-related applications Melanotan 2: Less receptor-selective (affects multiple melanocortin receptors) Associated with a broader range of biological effects Structurally shorter and more potent at lower doses Because of its receptor selectivity, Melanotan 1 is generally considered more targeted in its mechanism of action compared to Melanotan 2

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4,5 These factors assist in the assessment of the potential for nevus transformation into melanoma, and they include thickness of 2 mm or more, presence of subretinal fluid, symptoms such as metamorphopsia and photopsia, orange pigment, margin within 3 mm of the optic disc, ultrasonographic hollowness, absence of halo, and absence of drusen

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