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Unlike other gaseous signaling molecules such as carbon monoxide, nitric oxide (NO), and H 2 sulfide (H 2 S), H 2 has an excellent safety profile and exerts protective effects without toxicity risks, even at high concentrations [15, 16]

doi: 10.1096/fasebj.13.9.1007

However, most of the data is over ten years old and relies on BDNF-levels in peripheral blood mononuclear cells (PBMC) or serum, as BDNF-levels in Cerebrospinal fluid (CSF) are low and ultra-sensitive immunoassays are necessary for its reliable detection (60)

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In short, glutathione function is complex and context dependent