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Many studies have shown that certain biomaterials can provide three-dimensional structures suitable for stem cell growth to control undesirable migration, and can simultaneously be skilfully combined with biological factors or drugs that promote the differentiation of stem cells to NP cells, thereby promoting ECM secretion, inducing MSC differentiation to the NP cell phenotype, and accelerating IDD repair [91, 102, 103] (Fig

However, surgical evaluation may be appropriate for women with suspected deep infiltrating disease, large adnexal masses, or infertility evaluation

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Their appetite suppression does not kick in as reliably, or they feel like they are not getting the same effect from the same dose