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For example, in tumors with active growth factor receptor signaling (e.g., HER2 amplification), tamoxifen may lose its estrogen antagonist activity and acquire more agonist-like activity, resulting in tumor growth stimulation [34]
The BACH2 gene encodes a transcription factor that plays a role in the adaptive immune response involving T- and B-cells and is involved in apoptosis consequent to oxidative stress 41,42
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