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The combination also preserves the physiological pulsatile pattern of GH release, as both pathways remain subject to somatostatin feedback

By detecting relevant molecular biomarkers, implementing stratified treatment approaches, and dynamically adjusting therapeutic regimens, treatment efficacy can be maximized

For example, the nanoplatforminduced photothermal effect can induce Ca 2+ influx, which directly interferes with and suppresses the expression of the core clock proteins Bmal1 and Clock

10.1111/j.1582-4934.2010.01127.x [DOI] [PMC free article] [PubMed] [Google Scholar] 95.Vidya MK, Kumar VG, Sejian V, Bagath M, Krishnan G, Bhatta R