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In HFD-induced NAFLD rats, the hepatoprotective effect of Jiaogulan (Gynostemma pentaphyllum (Thunb.) Makino) has been correlated with specific modulations of the gut microbiota (e.g., a reduced Firmicutes/Bacteroidetes ratio, increased Lactococcus, decreased Ruminococcus) and the preservation of intestinal barrier integrity, pointing to microbiota-mediated pathways as a likely component of its action [133]
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Second, there are substantial differences in gut microbiota between animal models and humans
doi: 10.2147/DDDT.S72716 68 OBryanMKSchlattSGerdprasertOPhillipsDJde KretserDMHedgerMP
There is a shift toward natural, plant-based and clinically supported ingredients, transparency and scientific validation
