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The challenges of transferring these therapies to clinical use are likely dependent on the intricate and unknown essential molecular and cellular functions, as well as the healing pathways, physical structure, and pathophysiological characteristics of the CNS (Jiang et al., 2021)

10.1227/NEU.0000000000000341 Neurosurgery Summary Keywords traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), animal models of TBI, stress, neuroinflammation, calcium dysregulation, tauopathy Citation Fesharaki-Zadeh A and Datta D (2024) An overview of preclinical models of traumatic brain injury (TBI): relevance to pathophysiological mechanisms