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42, 125129.10.1016/S1579-2129(06)60130-4 25 ItzhakiS.DorchinH.ClarkG.LavieL.LavieP.PillarG

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The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases.[237] It is apparent that vitamin D has significant effects on the immune system and as such may contribute to the pathogenesis of autoimmune disease

Anti-Inflammatory Effects Metformin is thought to activate a key cellular regulator called AMP-activated protein kinase (AMPK), which is believed to be responsible for its anti-inflammatory effects

Cytoprotectants Amifostine Amifostine, an analog of cysteamine, is a phosphorylated aminothiol prodrug