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In summary, hypoglycemia without hyperinsulinemia should prompt consideration of paraneoplastic hypoglycemia, particularly in patients with a history of neoplasia, imaging evidence of cancer, or typical clinical features

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Overall, LA could induce lung cancer cell apoptosis by increasing ROS or Ca 2+ expression, reduce cell proliferation by suppressing Grb2-mediated EGFR phosphorylation, and inhibit autophagy by activating the mTOR pathway

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doi: 10.1016/j.bbi.2019.06.042 59 KumeT.Takada-TakatoriY

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*Correspondence: Paulo Mazzafera, Departamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, Rua Monteiro Lobato 255, CEP 13083-862, Campinas, SP, Brazil [email protected] This article was submitted to Plant Nutrition, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Metabolic studies Animals were given either 6 g/kg glucose or distilled water (2 mL/100 g body weight, n = 10 for all groups) by gavage every 6 h (at 06:20, 12:20, 18:20, and 24:20 h) for 38 days, defined as the long-term oscillating glucose (LOsG) or sham group

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