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The study by Wu, L

Even if a cosmetic product contains highly effective beauty ingredients, strong irritants can accumulate damage to the skin over time when used for extended periods

Hyperpigmentation was observed when this compound got oxidized and inactivated by factors such as heat, radiation and inflammation with consequent loss of the inhibitory effect on tyrosinase

Liu ZX, Azhipa O, Okamoto S, Govindarajan S, Dennert G

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