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Although these agents have been shown to be effective in vitro and in mice bearing drug-resistant human tumors, none thus far have been tested in clinical trials

105 These findings imply that oxidized POLG causes mtDNA mutation or depletion and in turn results in a variety of diseases

If binding occurred with a low affinity for TfR, the level of BACE1 penetration through the BBB is increased [184, 185]

In case of gene therapy methods, inappropriate gene insertions may occur, leading to malfunctions in the activity of brain structures

Increased LPL activity is mediated to a large extent by reduced hepatic production of apoC-III (an LPL inhibitor)