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doi: 10.1016/s0140-6736(11)61452-9 6 DarrasVMVan HerckSL
Neuro-oncology (2020) 22(2):18094
However, researchers still face challenges like the variability of data
A study conducted by Zhao and colleagues in 2022 documented that SIRT1 contributes to L-OHP resistance in CRC by controlling a pathway involving miR-20b-3p and DEP domain containing 1 (DEPDC1)
They propose that under the stimulation of the pro-inflammatory cytokine TNF- , IRF1 can directly bind to the GPX4 promoter region (1,498 to 1,239), affecting GPX4 transcription
