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The decreased proteasome activity induced by quercetin may not be reversed following suppression of the JNK and p38 MAPK signaling pathways

Additionally, optimizing HDL functionality, increasing nitric oxide production, and inhibiting the oxidation of LDL cholesterol are a number of other beneficial effects found in numerous studies with omega-3 supplementation, also in agreement with the adapted physiology found in fish and marine mammals that provide them with an added resistance to atherosclerosis, thus making omega-3-based supplements ideal for the prevention and treatment of cardiovascular diseases [41, 50]

10.1165/rcmb.2019-0177OC [DOI] [PMC free article] [PubMed] [Google Scholar] 88.Sotgia S, Paliogiannis P, Sotgiu E, Mellino S, Zinellu E, Fois AG, et al