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Organic nanoparticles, mainly polymer and lipid nanoparticles, hold great promise for delivering drugs into the brain

IGF-1R signaling decreases chemotherapeutic responses in breast cancer through multiple mechanisms, including promoting proliferation, enhancing cancer stemness, inhibiting apoptosis through DNA damage repair, and inducing efflux transporters [144,145]

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While conventional therapeutics are indispensable for improving quality of life in Parkinson's patients, they do not provide fundamental neuroprotection or support for neuronal mitochondria