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PMID: 37876311

Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375

B vitamins are water soluble so any excess is usually excreted - which means that they need to be regularly taken

Partial agonist imidazoline compounds (clonidine, moxonidine, and oxymetazoline) and phenylephrine induced less maximum internalization of 2C -ARs than full agonists (norepinephrine and UK14,304)