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[5] However, the pathway was fully elucidated only in the 1950s, thanks to the work of several researchers, notably Efraim Racker, Bernard Horecker, Frank Dickens, and Fritz Lipmann, who received the Nobel Prize in Physiology or Medicine in 1953 for his discovery of coenzyme A, not specifically for the pentose phosphate pathway, although his work was highly relevant in the broader context of intermediary metabolism

A classic clinical hallmark is aquagenic pruritus , characterized by severe itching following a hot shower due to histamine release from increased basophils

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Onset often occurs after a trigger event [1], such as viral infection, trauma, or toxin exposure, which induces a physiological response

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