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On the basis of the results available up to date, the Global Initiative for Chronic Obstructive Lung Disease [119] recognizes that mucolytic and antioxidant drugs, such as NAC, can be used as an adjunct therapy to reduce the risk of acute exacerbation of COPD, but in a limited way due to the lack of robust randomized controlled clinical trials (level of evidence B)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Lissoni P., Barni S., Cattaneo G., Tancini G., Esposti G., Esposti D., Fraschini F