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However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 2011)

Science Translational Medicine, 10(424), eaan6205

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One example is pairing tirzepatide with apitegromab, which showed promising results in early trials for muscle preservation
