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doi: 10.1007/s10597-018-0236-x

These results suggest that the differential metabolites are largely associated with core metabolic functions and stress responses, implying disruptions in energy homeostasis, membrane composition, and detoxification processes under diabetic conditions

And some are outright counterfeits

For researchers developing small-molecule inhibitors, nucleic acid therapeutics, uricosuric agents, or anti-inflammatory biologics, choosing the right animal model can directly influence the interpretability and translational value of preclinical data

MMN improvement was observed in the absence of robust changes in assessments of clinical severity, though the latter was observed in a larger and more prolonged clinical study