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Glutathione deficiency contributes to oxidative stress, which plays a role in several medical conditions

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Results from the biological evaluation, the acylamino compounds ( 31a 31g , Figure 11) exhibited potent tyrosinase inhibitors than kojic acid (IC 50 = 28.5 M), and in contrast, the aminophenones ( 31 h and 31i ) showed activation of tyrosinase activity